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Article

Hypomyelination following deletion of Tsc2 in oligodendrocyte precursors

27 Oct 2015

Abstract excerpt

OBJECTIVE: While abnormalities in myelin in tuberous sclerosis complex (TSC) have been known for some time, recent imaging-based data suggest myelin abnormalities may be independent of the pathognomonic cortical lesions ("tubers"). Multiple mouse models of TSC exhibit myelination deficits, though the cell types responsible and the mechanisms underlying the myelin abnormalities remain unclear. METHODS: To...

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Share to Amyotrophic Lateral Sclerosis Research
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PMID: 26734657
DOI: 10.1002/acn3.254

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