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Article

Myelination is delayed during postnatal brain development in the mdx mouse model of Duchenne muscular dystrophy

14 Aug 2017

Abstract excerpt

BACKGROUND: In Duchenne muscular dystrophy (DMD), the loss of the dystrophin component of the dystrophin-glycoprotein complex (DGC) compromises plasma membrane integrity in skeletal muscle, resulting in extensive muscle degeneration. In addition, many DMD patients exhibit brain deficits in which the cellular etiology remains poorly understood. We recently found that dystroglycan, a receptor component of the DGC...

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PMID: 28806929
DOI: 10.1186/s12868-017-0381-0

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