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Article

ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition.

Cell reports - 7 Feb 2017

Wang Belinda, Krall Elsa Beyer, Aguirre Andrew James, Kim Miju, Widlund Hans Ragnar, Doshi Mihir Bhavik, Sicinska Ewa, Sulahian Rita, Goodale Amy, Cowley Glenn Spencer, Piccioni Federica, Doench John Gerard, Root David Edward, Hahn William Chun

Abstract excerpt

Intrinsic resistance and RTK-RAS-MAPK pathway reactivation has limited the effectiveness of MEK and RAF inhibitors (MAPKi) in RAS- and RAF-mutant cancers. To identify genes that modulate sensitivity to MAPKi, we performed genome-scale CRISPR-Cas9 loss-of-function screens in two KRAS mutant pancreatic cancer cell lines treated with the MEK1/2 inhibitor trametinib. Loss of CIC, a transcriptional repressor of ETV1,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28178529
DOI: 10.1016/j.celrep.2017.01.031
PMCID: PMC5313047

Genes

CIC
ETV1
ETV4
ETV5
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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