Article

Genome-wide CRISPR/Cas9 Screens Reveal Shared and Bespoke Mechanisms of Resistance to SHP2 inhibition

2022-08-27

Abstract excerpt

SHP2 ( PTPN11 ) acts upstream of SOS1/2 to enable RAS activation. Allosteric inhibitors (SHP2is) stabilize SHP2 auto-inhibition, preventing activation by upstream stimuli. SHP2is block proliferation of RTK- or cycling RAS mutant-driven cancers and overcome adaptive resistance to other RAS-ERK pathway drugs. Several SHP2is are in clinical trials. To identify potential SHP2i resistance mechanisms, we performed geno...

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Literature Corpus work: 617f5a2c-0ae7-56c7-abe1-1d75a4f63539
DOI: 10.1101/2022.08.26.505487

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