Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cis-acting single nucleotide polymorphisms alter MicroRNA-mediated regulation of human brain-expressed transcripts.

Human molecular genetics - 15 Nov 2016

Ramachandran Shyam, Coffin Stephanie L, Tang Tin-Yun, Jobaliya Chintan D, Spengler Ryan M, Davidson Beverly L

Abstract excerpt

Substantial variability exists in the presentation of complex neurological disorders, and the study of single nucleotide polymorphisms (SNPs) has shed light on disease mechanisms and pathophysiological variability in some cases. However, the vast majority of disease-linked SNPs have unidentified pathophysiological relevance. Here, we tested the hypothesis that SNPs within the miRNA recognition element (MRE; the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Binding Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Databases, Genetic

Share to Gene Expression Regulation

Share to HEK293 Cells

Share to MicroRNAs

Share to Open Reading Frames

Source

Open in PubMed Open full text

Identifiers

PMID: 28171541
DOI: 10.1093/hmg/ddw317
PMCID: PMC5418741

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cis-acting single nucleotide polymorphisms alter MicroRNA-mediated regulation of human brain-expressed transcripts.PMID 28171541Read ↗

The Computational Analysis Conducted on miRNA Target Sites in Association with SNPs at 3'UTR of ADHD-implicated Genes.Semantic proximity Read ↗

MirSNP, a database of polymorphisms altering miRNA target sites, identifies miRNA-related SNPs in GWAS SNPs and eQTLs.Semantic proximity Read ↗

SNPs in human miRNA genes affect biogenesis and function.Semantic proximity Read ↗

A complex crosstalk between polymorphic microRNA target sites and AD prognosis.Semantic proximity Read ↗

Mining the 3'UTR of autism-implicated genes for SNPs perturbing microRNA regulation.Semantic proximity Read ↗

A functional SNP catalog of overlapping miRNA-binding sites in genes implicated in prion disease and other neurodegenerative disorders.Semantic proximity Read ↗

Genetic architecture of miRNA expression in human brain and its contribution to brain disordersSemantic proximity Read ↗

SNPs in microRNA target sites and their potential role in human disease.Semantic proximity Read ↗

Functional genetic variation of human miRNAs and phenotypic consequences.Semantic proximity Read ↗

Finding functional disease-associated non-coding variation using next-generation sequencingSemantic proximity Read ↗

MicroRNA target site polymorphisms and human disease.Semantic proximity Read ↗

Human genetic variation and its effect on miRNA biogenesis, activity and function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.