Article
Mining the 3'UTR of autism-implicated genes for SNPs perturbing microRNA regulation.
Genomics, proteomics & bioinformatics - 1 Apr 2014
Vaishnavi Varadharajan, Manikandan Mayakannan, Munirajan Arasambattu Kannan
Abstract excerpt
Autism spectrum disorder (ASD) refers to a group of childhood neurodevelopmental disorders with polygenic etiology. The expression of many genes implicated in ASD is tightly regulated by various factors including microRNAs (miRNAs), a class of noncoding RNAs ~22 nucleotides in length that function to suppress translation by pairing with 'miRNA recognition elements' (MREs) present in the 3'untranslated region...
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