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Article

The Aurora-A-Twist1 axis promotes highly aggressive phenotypes in pancreatic carcinoma.

Journal of cell science - 15 Mar 2017

Wang Jing, Nikhil Kumar, Viccaro Keith, Chang Lei, Jacobsen Max, Sandusky George, Shah Kavita

Abstract excerpt

We uncovered a crucial role for the Aurora kinase A (AURKA)-Twist1 axis in promoting epithelial-to-mesenchymal transition (EMT) and chemoresistance in pancreatic cancer. Twist1 is the first EMT-specific target of AURKA that was identified using an innovative screen. AURKA phosphorylates Twist1 at three sites, which results in its multifaceted regulation - AURKA inhibits its ubiquitylation, increases its...

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Source

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Identifiers

PMID: 28167680
DOI: 10.1242/jcs.196790
PMCID: PMC5358340

Genes

AURKA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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