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TWIST1 regulates HK2 ubiquitination degradation to promote pancreatic cancer invasion and metastasis

7 Feb 2025

Abstract excerpt

OBJECTIVE: TWIST1 is known to promote glycolysis and contribute to pancreatic cancer development; however, its underlying mechanisms remain poorly understood. This study aims to elucidate the molecular mechanisms by which TWIST1 influences aerobic glycolysis in pancreatic ductal adenocarcinoma (PDAC). METHODS: The expression levels of TWIST1, MMP9, MT1-MMP, and FDX1 in clinical tissues and cancer cell lines were...

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PMID: 39920765
DOI: 10.1186/s12935-024-03583-z

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