Article
Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-κB binding that is linked to immune phenotypes.
BMC genomics - 6 Feb 2017
Singh Prashant K, van den Berg Patrick R, Long Mark D, Vreugdenhil Angie, Grieshober Laurie, Ochs-Balcom Heather M, Wang Jianmin, Delcambre Sylvie, Heikkinen Sami, Carlberg Carsten, Campbell Moray J, Sucheston-Campbell Lara E
Abstract excerpt
BACKGROUND: The nuclear hormone receptor superfamily acts as a genomic sensor of diverse signals. Their actions are often intertwined with other transcription factors. Nuclear hormone receptors are targets for many therapeutic drugs, and include the vitamin D receptor (VDR). VDR signaling is pleotropic, being implicated in calcaemic function, antibacterial actions, growth control, immunomodulation and anti-cancer...
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