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Mitotic spindle disruption in human preimplantation embryos activates the spindle assembly checkpoint but not apoptosis until Day 5 of development

31 Jan 2017

Abstract excerpt

STUDY QUESTION: Is the spindle assembly checkpoint (SAC) active during human preimplantation development? SUMMARY ANSWER: Mitotic spindle disruption during mitosis activates the SAC from at least Day 3 of human preimplantation development, but this does not lead to apoptosis until Day 5. WHAT IS KNOWN ALREADY: Human preimplantation embryos frequently acquire chromosomal abnormalities, but the mechanisms behind...

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PMID: 28159965
DOI: 10.1093/molehr/gax007

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