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Article

Human apoA-I[Lys107del] mutation affects lipid surface behavior of apoA-I and its ability to form large nascent HDL.

Journal of lipid research - 1 Feb 2023

Gorshkova Irina N, Meyers Nathan L, Herscovitz Haya, Mei Xiaohu, Atkinson David

Abstract excerpt

Population studies have found that a natural human apoA-I variant, apoA-I[K107del], is strongly associated with low HDL-C but normal plasma apoA-I levels. We aimed to reveal properties of this variant that contribute to its unusual phenotype associated with atherosclerosis. Our oil-drop tensiometry studies revealed that compared to WT, recombinant apoA-I[K107del] adsorbed to surfaces of POPC-coated triolein drops...

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Identifiers

PMID: 36525992
DOI: 10.1016/j.jlr.2022.100319
PMCID: PMC9926306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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