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Article

A Temporal Perspective on the Interplay of Demography and Selection on Deleterious Variation in Humans.

G3 (Bethesda, Md.) - 10 Mar 2017

Koch Evan, Novembre John

Abstract excerpt

When mutations have small effects on fitness, population size plays an important role in determining the amount and nature of deleterious genetic variation. The extent to which recent population size changes have impacted deleterious variation in humans has been a question of considerable interest and debate. An emerging consensus is that the Out-of-Africa bottleneck and subsequent growth events have been too...

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Identifiers

PMID: 28159863
DOI: 10.1534/g3.117.039651
PMCID: PMC5345704

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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