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Article

Ribosomal Protein S3 Negatively Regulates Unwinding Activity of RecQ-like Helicase 4 through Their Physical Interaction.

The Journal of biological chemistry - 10 Mar 2017

Patil Ajay Vitthal, Hsieh Tao-Shih

Abstract excerpt

Human RecQ-like helicase 4 (RECQL4) plays crucial roles in replication initiation and DNA repair; however, the contextual regulation of its unwinding activity is not fully described. Mutations in RECQL4 have been linked to three diseases including Rothmund-Thomson syndrome, which is characterized by osteoskeletal deformities, photosensitivity, and increased osteosarcoma susceptibility. Understanding regulation of...

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Source

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Identifiers

PMID: 28159839
DOI: 10.1074/jbc.M116.764324
PMCID: PMC5354493

Genes

RECQL4
RPS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Ribosomal Protein S3 Negatively Regulates Unwinding Activity of RecQ-like Helicase 4 through Their Physical Interaction.PMID 28159839Read ↗

Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4.Semantic proximity Read ↗

An overview of RecQ helicases and related diseases.Semantic proximity Read ↗

Human RecQ Helicases in DNA Double-Strand Break RepairSemantic proximity Read ↗

RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activity.Semantic proximity Read ↗

Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.Semantic proximity Read ↗

RECQ DNA helicases and osteosarcoma.Semantic proximity Read ↗

Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome.Semantic proximity Read ↗

Human RecQL4 as a Novel Molecular Target for Cancer Therapy.Semantic proximity Read ↗

The RECQL4 protein, deficient in Rothmund–Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesionsSemantic proximity Read ↗

RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structuresSemantic proximity Read ↗

RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stressSemantic proximity Read ↗

The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stabilitySemantic proximity Read ↗

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