Article
Single nucleotide polymorphisms of IL-2, but not IL-12 and IFN-γ, are associated with increased susceptibility to chronic spontaneous urticaria.
Allergologia et immunopathologia - 1 Jan 2000
Movahedi M, Tavakol M, Rahmani F, Amirzargar A A, Bidoki A Z, Heidari K, Gharagozlou M, Aghamohammadi A, Nabavi M, Soltani S, Rezaei N
Abstract excerpt
BACKGROUND: A clear picture of interaction of Th1/Th2 cytokines in pathogenesis of chronic spontaneous urticaria (CSU), remains elusive. Impaired IFN-γ production and decreased levels of IL-2 have been reported. The aim of this study was to evaluate the association of Th1 cytokines; IL-2, IL-12 and IFN-γ polymorphisms with CSU. METHODS: 90 patients with CSU and 140 age-sex matched subjects were included in this...
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