Article
Circulating fibronectin contributes to mesangial expansion in a murine model of type 1 diabetes.
Kidney international - 1 Jun 2017
Klemis Verena, Ghura Hiba, Federico Giuseppina, Würfel Carina, Bentmann Anke, Gretz Norbert, Miyazaki Tatsuhiko, Gröne Hermann-Joseph, Nakchbandi Inaam A
Abstract excerpt
Fibronectin is ubiquitously expressed in the extracellular matrix, and its accumulation in the glomerular mesangium in diabetic nephropathy is associated with deterioration of renal function in these patients. However, the exact role of fibronectin in the pathogenesis of diabetic nephropathy remains unknown. To clarify this, we administered fluorescent-labeled plasma fibronectin to wild-type mice and found it to...
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