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Article

Connective tissue growth factor (CTGF) expression modulates response to high glucose.

PloS one - 1 Jan 2013

James Leighton R, Le Catherine, Doherty Heather, Kim Hyung-Suk, Maeda Nobuyo

Abstract excerpt

Connective tissue growth factor (CTGF) is an important mediator of fibrosis; emerging evidence link changes in plasma and urinary CTGF levels to diabetic kidney disease. To further ascertain the role of CTGF in responses to high glucose, we assessed the consequence of 4 months of streptozotocin-induced diabetes in wild type (+/+) and CTGF heterozygous (+/-) mice. Subsequently, we studied the influence of glucose...

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Identifiers

PMID: 23950936
DOI: 10.1371/journal.pone.0070441
PMCID: PMC3741286

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