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Article

Reduced production of diacetyl by overexpressing BDH2 gene and ILV5 gene in yeast of the lager brewers with one ILV2 allelic gene deleted.

Journal of industrial microbiology & biotechnology - 1 Mar 2017

Shi Ting-Ting, Li Ping, Chen Shi-Jia, Chen Ye-Fu, Guo Xue-Wu, Xiao Dong-Guang

Abstract excerpt

Diacetyl causes an unwanted buttery off-flavor in lager beer. The production of diacetyl is reduced by modifying the metabolic pathway of yeast in the beer fermentation process. In this study, BDH2 and ILV5 genes, coding diacetyl reductase and acetohydroxy acid reductoisomerase, respectively, were expressed using a PGK1 promoter in Saccharomyces cerevisiae, which deleted one ILV2 allelic gene. Diacetyl contents...

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Source

Identifiers

PMID: 28154948
DOI: 10.1007/s10295-017-1903-6

Genes

BDH2
PGK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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