Article
Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage.
Disease models & mechanisms - 1 Mar 2017
Yang Ran, Zhang Yunpei, Huang Dandan, Luo Xiao, Zhang Liangren, Zhu Xiaojun, Zhang Xiaolin, Liu Zhenming, Han Jing-Yan, Xiong Jing-Wei
Abstract excerpt
Hemorrhagic stroke accounts for 10-15% of all strokes and is strongly associated with mortality and morbidity worldwide, but its prevention and therapeutic interventions remain a major challenge. Here, we report the identification of miconazole as a hemorrhagic suppressor by a small-molecule screen in zebrafish. We found that a hypomorphic mutant fn40a, one of several known β-pix mutant alleles in zebrafish, had...
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