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Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia

2 Feb 2017

Abstract excerpt

Methylation of N 6 adenosine (m 6 A) is known to be important for diverse biological processes including gene expression control, translation of protein, and messenger RNA (mRNA) splicing. However, its role in the development of human cancers is poorly understood. By analyzing datasets from the Cancer Genome Atlas Research Network (TCGA) acute myeloid leukemia (AML) study, we discover that mutations and/or copy...

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PMID: 28153030
DOI: 10.1186/s13045-017-0410-6

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