Article

Single-cell transcriptome profiling of m6A regulator-mediated methylation modification patterns in elderly AML patients

2024-06-06

Abstract excerpt

<title>Abstract</title> Millions of people worldwide die of acute myeloid leukaemia (AML) each year. Although N6-methyladenosine (m6A) modification has been reported to regulate the pathogenicity of AML, the mechanism by which it induces the dysfunctional differentiation of haemocytes in elderly AML patients remains unclear. In this study, we illustrated the underlying mechanisms of the m6</sup...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 38b12592-4871-547f-94a0-641cdf393885
DOI: 10.21203/rs.3.rs-4435634/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell transcriptome profiling of m6A regulator-mediated methylation modification patterns in elderly AML patientsDOI 10.21203/rs.3.rs-4435634/v1Read

Comprehensive analysis of the landscape characteristics of m6A regulators in acute myeloid leukemiaSemantic proximity Read

Genetic characteristics and prognosis of m6A RNAmethylation regulator in acute myeloid leukemiaSemantic proximity Read

m6A regulator-based methylation modification patterns and characterization of tumor microenvironment in acute myeloid leukemiaSemantic proximity Read

The RNA N⁶-Methyladenosine Methylome Coordinates Long Non-Coding RNAs to Mediate Cancer Drug Resistance by Activating PI3K SignalingSemantic proximity Read

m6A genotypes and prognostic signature for assessing the prognosis of patients with acute myeloid leukemia.Semantic proximity Read

Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemiaSemantic proximity Read

N6-Methyladenosine Role in Cancer: Learning from AMLSemantic proximity Read

m6A mRNA Methylation in Hematopoiesis: The Importance of Writing, Erasing, and ReadingSemantic proximity Read

Transcriptional regulatory networks mediated by abnormal m6A modifications in tumor developmentSemantic proximity Read

m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Acute Myeloid Leukemia.Semantic proximity Read

Proteomic subtypes enrich current acute myeloid leukemia nomenclature and reflect intrinsic pathogenesis alongside agingSemantic proximity Read