Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant.

doi:10.1111/adb.12491

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Article

Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant.

Addiction biology - 1 Jan 2018

Sloan Matthew E, Gowin Joshua L, Yan Jia, Schwandt Melanie L, Spagnolo Primavera A, Sun Hui, Hodgkinson Colin A, Goldman David, Ramchandani Vijay A

Abstract excerpt

The endocannabinoid system plays an important role in reward and addiction. One of the two main endocannabinoid neurotransmitters, anandamide, is metabolized by fatty acid amide hydrolase, an enzyme with a functional genetic polymorphism (FAAH Pro129Thr, rs324420). The Thr129 allele has been linked to problem drug and alcohol use, but the association has not been widely replicated and may be stronger for clinical...

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PMID: 28150397
DOI: 10.1111/adb.12491
PMCID: PMC5538894

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FAAH

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