Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk.

doi:10.1111/adb.12571

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Article

Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk.

Addiction biology - 1 Jan 2019

Bach Patrick, Zois Evangelos, Vollstädt-Klein Sabine, Kirsch Martina, Hoffmann Sabine, Jorde Anne, Frank Josef, Charlet Katrin, Treutlein Jens, Beck Anne, Heinz Andreas, Walter Henrik, Rietschel Marcella, Kiefer Falk

Abstract excerpt

Alcohol metabolizing enzymes, such as the alcohol dehydrogenases and the aldehyde dehydrogenases, regulate the levels of acetaldehyde in the blood and play an important role in the development and maintenance of alcohol addiction. Recent genome-wide systematic searches found associations between a single nucleotide polymorphism (rs1789891, risk allele: A, protective allele: C) in the alcohol dehydrogenase gene...

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PMID: 29058369
DOI: 10.1111/adb.12571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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