Article

Readthrough approach by NV translational readthrough inducing drugs (TRIDs): a study of the possible off-target effects on natural termination codons (NTCs) on TP53 and housekeeping genes expression.

2023-08-11

Abstract excerpt

Nonsense mutations cause several genetic diseases such as Cystic fibrosis, Duchenne muscular dystrophy, β-thalassemia, and Shwachman-Diamond syndrome. These mutations induce the formation of a premature termination codon (PTC) inside the mRNA sequence that leads to the aberrant translation, resulting in the synthesis of truncated polypeptides. Nonsense suppression therapy mediated by translational readthrough-indu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2dbb36d8-855d-53be-921d-e47fa89c2e90
DOI: 10.20944/preprints202308.0959.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Readthrough approach by NV translational readthrough inducing drugs (TRIDs): a study of the possible off-target effects on natural termination codons (NTCs) on TP53 and housekeeping genes expression.DOI 10.20944/preprints202308.0959.v1Read

Targeting Nonsense Mutations in Diseases with Translational Read-Through-Inducing Drugs (TRIDs).Semantic proximity Read

Advances in therapeutic use of a drug-stimulated translational readthrough of premature termination codonsSemantic proximity Read

Readthrough Activators and Nonsense-Mediated mRNA Decay Inhibitor Molecules: Real Potential in Many Genetic Diseases Harboring Premature Termination CodonsSemantic proximity Read

Readthrough compounds for nonsense mutations: bridging the translational gap.Semantic proximity Read

Molecular Insights into Determinants of Translational Readthrough and Implications for Nonsense Suppression Approaches.Semantic proximity Read

Therapeutic suppression of premature termination codons: mechanisms and clinical considerations (review).Semantic proximity Read

Combining Translation Readthrough Inducing Drugs and Nonsense Mediated Decay Pathway Inhibition to Rescue of CFTRW1282X in Cystic Fibrosis Cell Model SystemSemantic proximity Read

Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough.Semantic proximity Read

Advancing translational readthrough therapies: genetic and mechanistic insights in Choroideremia nonsense mutation modelsSemantic proximity Read

Effect of Readthrough Treatment in Fibroblasts of Patients Affected by Lysosomal Diseases Caused by Premature Termination Codons.Semantic proximity Read

Novel small molecules potentiate premature termination codon readthrough by aminoglycosides.Semantic proximity Read

Optimized approach for the identification of highly efficient correctors of nonsense mutations in human diseases.Semantic proximity Read