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Article

Molecular, morphological and survival analysis of 177 resected pancreatic ductal adenocarcinomas (PDACs): Identification of prognostic subtypes.

Scientific reports - 1 Feb 2017

Schlitter Anna Melissa, Segler Angela, Steiger Katja, Michalski Christoph W, Jäger Carsten, Konukiewitz Björn, Pfarr Nicole, Endris Volker, Bettstetter Markus, Kong Bo, Regel Ivonne, Kleeff Jörg, Klöppel Günter, Esposito Irene

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) has generally a poor prognosis, but recent data suggest that there are molecular subtypes differing in clinical outcome. This study examines the association between histopathologic heterogeneity, genetic profile, and survival. Tumor histology from 177 resected PDAC patients with follow-up data was subclassified according to predominant growth pattern, and four key genes...

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Identifiers

PMID: 28145465
DOI: 10.1038/srep41064
PMCID: PMC5286512

Genes

KRAS
SMAD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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