Article
Simultaneous Modeling of Disease Status and Clinical Phenotypes To Increase Power in Genome-Wide Association Studies.
Genetics - 1 Mar 2017
Bilow Michael, Crespo Fernando, Pan Zhicheng, Eskin Eleazar, Eyheramendy Susana
Abstract excerpt
Genome-wide association studies have identified thousands of variants implicated in dozens of complex diseases. Most studies collect individuals with and without disease and search for variants with different frequencies between the groups. For many of these studies, additional disease traits are also collected. Jointly modeling clinical phenotype and disease status is a promising way to increase power to detect...
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