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Article

Cell Cycle-independent Role of Cyclin D3 in Host Restriction of Influenza Virus Infection

28 Jan 2017

Abstract excerpt

To identify new host factors that modulate the replication of influenza A virus, we performed a yeast two-hybrid screen using the cytoplasmic tail of matrix protein 2 from the highly pathogenic H5N1 strain. The screen revealed a high-score interaction with cyclin D3, a key regulator of cell cycle early G 1 phase. M2-cyclin D3 interaction was validated through GST pull-down and recapitulated in influenza...

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PMID: 28130444
DOI: 10.1074/jbc.m117.776112

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