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Article

Mutations in the cytoplasmic domain of dengue virus NS4A affect virus fitness and interactions with other non-structural proteins.

The Journal of general virology - 1 Sept 2020

Tan Min Jie Alvin, Brown Nancy G, Chan Kitti Wing Ki, Jin Jocelyn Y, Zu Kong Sean Yao, Vasudevan Subhash G

Abstract excerpt

The dengue virus (DENV) replication complex is made up of its non-structural (NS) proteins and yet-to-be identified host proteins, but the molecular interactions between these proteins are not fully elucidated. In this work, we sought to uncover the interactions between DENV NS1 and its fellow NS proteins using a yeast two-hybrid (Y2H) approach, and found that domain II of NS1 binds to an N-terminal cytoplasmic...

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Identifiers

PMID: 32589122
DOI: 10.1099/jgv.0.001462

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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