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Article

Vagal innervation is required for pulmonary function phenotype in Htr4-/- mice.

American journal of physiology. Lung cellular and molecular physiology - 1 Apr 2017

House John S, Nichols Cody E, Li Huiling, Brandenberger Christina, Virgincar Rohan S, DeGraff Laura M, Driehuys Bastiaan, Zeldin Darryl C, London Stephanie J

Abstract excerpt

Human genome-wide association studies have identified over 50 loci associated with pulmonary function and related phenotypes, yet follow-up studies to determine causal genes or variants are rare. Single nucleotide polymorphisms in serotonin receptor 4 (HTR4) are associated with human pulmonary function in genome-wide association studies and follow-up animal work has demonstrated that Htr4 is causally associated...

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Source

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Identifiers

PMID: 28130264
DOI: 10.1152/ajplung.00495.2016
PMCID: PMC5407097

Genes

HTR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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