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Article

Serotonin-induced smooth muscle hyperplasia in various forms of human pulmonary hypertension.

Circulation research - 14 May 2004

Marcos Elisabeth, Fadel Elie, Sanchez Olivier, Humbert Marc, Dartevelle Philippe, Simonneau Gerald, Hamon Michel, Adnot Serge, Eddahibi Saadia

Abstract excerpt

Hyperplasia of pulmonary artery smooth muscle cells (PA-SMCs) is a hallmark pathological feature of pulmonary hypertension (PH). Serotonin (5-HT) is involved in the hyperplasia through its interactions with specific receptors and internalization by a specific plasma membrane transporter. We investigated the expression and role of the 5-HT transporter (5-HTT) and 5-HT1B, 5-HT2A, and 5-HT2B receptors in lungs and...

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Identifiers

PMID: 15059929
DOI: 10.1161/01.RES.0000126847.27660.69

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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