Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4.

Journal of human genetics - 1 Jan 2001

Lev-Lehman E, Bercovich D, Xu W, Stockton D W, Beaudet A L

Abstract excerpt

Most neuronal nicotinic acetylcholine receptors are heteropentamers, composed of alpha and beta subunits. Mice lacking the alpha3 subunit and mice lacking both the beta2 and beta4 subunits, but not mice lacking the beta2 or beta4 subunits alone, have a severe phenotype characterized by megacystis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autonomic Nervous System Diseases
Share to Chromosome Mapping
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Library

Share to Introns

Share to Protein Subunits

Share to Receptors, Nicotinic

Source

Identifiers

PMID: 11450844
DOI: 10.1007/PL00010921

Genes

CHRNA3
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11450844-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4.PMID 11450844Read ↗

Megacystis, mydriasis, and ion channel defect in mice lacking the alpha3 neuronal nicotinic acetylcholine receptor.Semantic proximity Read ↗

CAKUT and Autonomic Dysfunction Caused by Acetylcholine Receptor Mutations.Semantic proximity Read ↗

The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer.Semantic proximity Read ↗

Megacystis-microcolon-intestinal hypoperistalsis syndrome and the absence of the alpha3 nicotinic acetylcholine receptor subunit.Semantic proximity Read ↗

The CHRNA5–A3–B4 Gene Cluster and Smoking: From Discovery to TherapeuticsSemantic proximity Read ↗

Five New Cases of Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome (MMIHS), with One Case Showing a Novel Mutation.Semantic proximity Read ↗

Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior.Semantic proximity Read ↗

Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumptionSemantic proximity Read ↗

Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions.Semantic proximity Read ↗

Muscarinic Acetylcholine Receptor M3 Mutation Causes Urinary Bladder Disease and a Prune-Belly-like SyndromeSemantic proximity Read ↗

Clinical, molecular, physiologic, and therapeutic feature of patients with CHRNA4 and CHRNB2 deficiency: A systematic review.Semantic proximity Read ↗

Naturally occurring genetic variability in the nicotinic acetylcholine receptor alpha4 and alpha7 subunit genes and phenotypic diversity in humans and mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.