Article
Cholinergic neuroplasticity in asthma driven by TrkB signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2020
Dragunas Guilherme, Woest Manon E, Nijboer Susan, Bos Sophie T, van Asselt Janet, de Groot Anne P, Vohlídalová Eva, Vermeulen Corneel J, Ditz Benedikt, Vonk Judith M, Koppelman Gerard H, van den Berge Maarten, Ten Hacken Nick H T, Timens Wim, Munhoz Carolina D, Prakash Y S, Gosens Reinoud, Kistemaker Loes E M
Abstract excerpt
Parasympathetic neurons in the airways control bronchomotor tone. Increased activity of cholinergic neurons are mediators of airway hyperresponsiveness (AHR) in asthma, however, mechanisms are not elucidated. We describe remodeling of the cholinergic neuronal network in asthmatic airways driven by brain-derived neurotrophic factor (BDNF) and Tropomyosin receptor kinase B (TrkB). Human bronchial biopsies were...
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