Article
The role of Alg13 N-acetylglucosaminyl transferase in the expression of pathogenic features of Candida albicans.
Biochimica et biophysica acta. General subjects - 1 Apr 2017
Niewiadomska Monika, Janik Anna, Perlińska-Lenart Urszula, Piłsyk Sebastian, Palamarczyk Grażyna, Kruszewska Joanna S
Abstract excerpt
BACKGROUND: The pathogenic potential of Candida albicans depends on adhesion to the host cells mediated by highly glycosylated adhesins, hyphae formation and growth of biofilm. These factors require effective N-glycosylation of proteins. Here, we present consequences of up- and down-regulation of the newly identified ALG13 gene encoding N-acetylglucosaminyl transferase, a potential member of the...
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