Article
CD244 maintains the proliferation ability of leukemia initiating cells through SHP-2/p27kip1 signaling.
Haematologica - 1 Apr 2017
Zhang Feifei, Liu Xiaoye, Chen Chiqi, Zhu Jun, Yu Zhuo, Xie Jingjing, Xie Li, Bai Haitao, Zhang Yaping, Fang Xia, Gu Hao, Wang Chun, Weng Wei, Zhang Cheng Cheng, Chen Guo-Qiang, Liang Aibing, Zheng Junke
Abstract excerpt
Targeting leukemia initiating cells is considered to be an effective way to cure leukemia, for which it is critical to identify novel therapeutic targets. Herein, we demonstrate that CD244, which was initially reported as a key regulator for natural killer cells, is highly expressed on both mouse and human leukemia initiating cells. Upon CD244 knockdown, human leukemia cell lines and primary leukemia cells have...
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