Article
Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors.
Cancer letters - 28 Apr 2017
Zhang Ming, Singh Ratnakar, Peng Shaohua, Mazumdar Tuhina, Sambandam Vaishnavi, Shen Li, Tong Pan, Li Lerong, Kalu Nene N, Pickering Curtis R, Frederick Mitchell, Myers Jeffrey N, Wang Jing, Johnson Faye M
Abstract excerpt
The genomic alterations identified in head and neck squamous cell carcinoma (HNSCC) tumors have not resulted in any changes in clinical care, making the development of biomarker-driven targeted therapy for HNSCC a major translational gap in knowledge. To fill this gap, we used 59 molecularly characterized HNSCC cell lines and found that mutations of AJUBA, SMAD4 and RAS predicted sensitivity and resistance to...
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