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Article

Epithelial-Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor-Mediated Apoptosis in Non-Small Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2016

Ferrarotto Renata, Goonatilake Ruchitha, Yoo Suk Young, Tong Pan, Giri Uma, Peng Shaohua, Minna John, Girard Luc, Wang Yuehong, Wang Liguang, Li Lerong, Diao Lixia, Peng David H, Gibbons Don L, Glisson Bonnie S, Heymach John V, Wang Jing, Byers Lauren A, Johnson Faye M

Abstract excerpt

PURPOSE: To identify new therapeutic targets for non-small cell lung cancer (NSCLC), we systematically searched two cancer cell line databases for sensitivity data on a broad range of drugs. We identified polo-like kinase 1 (PLK1) as the most promising target for further investigation based on a subset of sensitive NSCLC cell lines and inhibitors that were in advanced clinical development. EXPERIMENTAL DESIGN: To...

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Identifiers

PMID: 26597303
DOI: 10.1158/1078-0432.CCR-14-2890
PMCID: PMC4818738

Genes

PLK1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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