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Article

Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease

27 Dec 2012

Abstract excerpt

Mitochondrial dysfunction is one of the most early and prominent features in vulnerable neurons in the brain of Alzheimer's disease (AD) patients. Recent studies suggest that mitochondria are highly dynamic organelles characterized by a delicate balance of fission and fusion, a concept that has revolutionized our basic understanding of the regulation of mitochondrial structure and function which has far-reaching...

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PMID: 22531428
DOI: 10.3233/jad-2012-129005

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