Article
Insular primary glioblastomas with IDH mutations: Clinical and biological specificities.
Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Jun 2017
Hata Nobuhiro, Hatae Ryusuke, Yoshimoto Koji, Murata Hideki, Kuga Daisuke, Akagi Yojiro, Sangatsuda Yuhei, Suzuki Satoshi O, Iwaki Toru, Mizoguchi Masahiro, Iihara Koji
Abstract excerpt
Isocitrate dehydrogenase (IDH) mutation is a good prognostic marker for glioblastoma (GBM). Although it is infrequent in primary tumors, it is found in most lower-grade gliomas. Thus, it is unclear whether IDH mutation is a marker for a specific phenotype of apparently primary de novo GBMs (pGBMs), or a marker for secondary tumors (sGBMs). We addressed this issue by analyzing clinical, radiographic and molecular...
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