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Article

O-GlcNAc Transferase Is Essential for Sensory Neuron Survival and Maintenance

23 Jan 2017

Abstract excerpt

O-GlcNAc transferase (OGT) regulates a wide range of cellular processes through the addition of theO-GlcNAc sugar moiety to thousands of protein substrates. Because nutrient availability affects the activity of OGT, its role has been broadly studied in metabolic tissues. OGT is enriched in the nervous system, but little is known about its importance in basic neuronal processesin vivo. Here, we show that OGT is...

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PMID: 28115479
DOI: 10.1523/jneurosci.3384-16.2017

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