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Article

Glial Cell Responses and Gene Expression Dynamics in Retinas of Treated and Untreated RPE65 Mutant Dogs.

Investigative ophthalmology & visual science - 1 Oct 2024

Appelbaum Tatyana, Santana Evelyn, Smith David A, Beltran William A, Aguirre Gustavo D

Abstract excerpt

Purpose: The long-term evaluation of RPE65 gene augmentation initiated in middle-aged RPE65 mutant dogs previously uncovered notable inter-animal and intra-retinal variations in treatment efficacy. The study aims to gain deeper insights into the status of mutant retinas and assess the treatment impact. Methods: Immunohistochemistry utilizing cell-specific markers and reverse transcription-quantitative PCR...

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Source

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Identifiers

PMID: 39392441
DOI: 10.1167/iovs.65.12.18
PMCID: PMC11472885

Genes

RPE65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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