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Article

Group Behavior and Emergence of Cancer Drug Resistance.

Trends in cancer - 1 Apr 2021

Bhattacharya Supriyo, Mohanty Atish, Achuthan Srisairam, Kotnala Sourabh, Jolly Mohit Kumar, Kulkarni Prakash, Salgia Ravi

Abstract excerpt

Drug resistance is a major impediment in cancer. Although it is generally thought that acquired drug resistance is due to genetic mutations, emerging evidence indicates that nongenetic mechanisms also play an important role. Resistance emerges through a complex interplay of clonal groups within a heterogeneous tumor and the surrounding microenvironment. Traits such as phenotypic plasticity, intercellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33622644
DOI: 10.1016/j.trecan.2021.01.009
PMCID: PMC8500356

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