Severe damage to the placental fetal capillary network causes mid‐ to late fetal lethality and reduction in placental size in Peg11/Rtl1 KO mice

Abstract excerpt

Paternally expressed 11/Retrotransposon-like 1 (Peg11/Rtl1) knockout (KO) mice show mid- to late fetal lethality or late fetal growth retardation associated with frequent neonatal lethality. The lethal phenotype is largely dependent on genetic background and becomes more severe with each succeeding generation in the course of backcross experiments to C57BL/6 (B6). We previously suggested that these lethal and...

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