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Article

PEG10 viral aspartic protease domain is essential for the maintenance of fetal capillary structure in the mouse placenta

24 Sept 2021

Abstract excerpt

The therian-specific gene paternally expressed 10 (Peg10) plays an essential role in placenta formation: Peg10 knockout mice exhibit early embryonic lethality as a result of severe placental defects. The PEG10 protein exhibits homology with long terminal repeat (LTR) retrotransposon GAG and POL proteins; therefore, we generated mice harboring a mutation in the highly conserved viral aspartic protease motif in the...

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PMID: 34559199
DOI: 10.1242/dev.199564

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