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Article

Shifting Balance on a Static Mutation-Selection Landscape: A Novel Scenario of Positive Selection.

Molecular biology and evolution - 1 Feb 2017

Jones Christopher T, Youssef Noor, Susko Edward, Bielawski Joseph P

Abstract excerpt

A version of the mechanistic mutation-selection (MutSel) model that accounts for temporal dynamics at a site is presented. This is used to show that the rate ratio dN/dS at a site can be transiently >1 even when fitness coefficients are fixed or the fitness landscape is static. This occurs whenever a site drifts away from its fitness peak and is then forced back by selection, a process reminiscent of shifting...

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PMID: 28110273
DOI: 10.1093/molbev/msw237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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