Article
BanI polymorphism of cytosolic phospholipase A2 gene and somatic symptoms in medication-free acute depressed patients.
Prostaglandins, leukotrienes, and essential fatty acids - 1 Sept 2018
Chang Jane Pei-Chen, Guu Ta-Wei, Chen Yi-Chih, Gałecki Piotr, Walczewska Anna, Su Kuan-Pin
Abstract excerpt
Somatic symptoms are commonly seen in patients with major depressive disorder (MDD) and might be associated with inflammatory activation. Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression. This study investigated the effects of...
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