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Article

The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis.

Oncotarget - 28 Feb 2017

De Luca Anastasia, Carpanese Debora, Rapanotti Maria Cristina, Viguria Tara Mayte Suarez, Forgione Maria Antonietta, Rotili Dante, Fulci Chiara, Iorio Egidio, Quintieri Luigi, Chimenti Sergio, Bianchi Luca, Rosato Antonio, Caccuri Anna Maria

Abstract excerpt

The novel nitrobenzoxadiazole (NBD) derivative MC3181 is endowed with remarkable therapeutic activity in mice bearing both sensitive and vemurafenib-resistant human melanoma xenografts. Here, we report that subtoxic concentrations of this compound significantly reduced invasiveness of BRAF-V600D mutated WM115 and WM266.4 melanoma cell lines derived from the primary lesion and related skin metastasis of the same...

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Source

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Identifiers

PMID: 28107182
DOI: 10.18632/oncotarget.14690
PMCID: PMC5362503

Genes

BRAF
MCAM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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