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Article

Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAFV600E/p38α inhibitors.

European journal of medicinal chemistry - 5 Apr 2021

Ali Eslam M H, El-Telbany Rania Farag A, Abdel-Maksoud Mohammed S, Ammar Usama M, Mersal Karim I, Zaraei Seyed-Omar, El-Gamal Mohammed I, Choi Se-In, Lee Kyung-Tae, Kim Hee-Kwon, Lee Kwan Hyi, Oh Chang-Hyun

Abstract excerpt

The synergistic effect of dual inhibition of serine/threonine protein kinases that are involved in the same signalling pathway of the diseases can exert superior biological benefits for treatment of these diseases. In the present work, a new series of (imidazol-5-yl)pyrimidine was designed and synthesized as dual inhibitors of BRAFV600E and p38α kinases which are considered as key regulators in mitogen-activated...

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Identifiers

PMID: 33601311
DOI: 10.1016/j.ejmech.2021.113277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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