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Article

Discovery and pharmacophore studies of novel pyrazole-based anti-melanoma agents.

Chemistry & biodiversity - 1 Jan 2015

Li Qing-Shan, Lü Xian-Hai, Yang Yang, Ruan Ban-Feng, Yao Ri-Sheng, Liao Chen-Zhong

Abstract excerpt

Due to the rising incidence and lack of effective treatments, malignant melanoma is the most dangerous form of skin cancer, so that new treatment strategies are urgently needed. Several recent developments indicate that the V600E mutant BRAF (BRAF(V600E) ) is a validated target for antimelanoma-drug development. Based on in silico screening results, a series of novel pyrazole derivatives has been designed,...

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Source

Identifiers

PMID: 25641840
DOI: 10.1002/cbdv.201400143

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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