Article
Genes of susceptibility to early neurodegenerative changes in the rat retina and brain: analysis by means of congenic strains.
BMC genetics - 22 Dec 2016
Korbolina Elena E, Zhdankina Anna A, Fursova Anzhela Zh, Kozhevnikova Oyuna S, Kolosova Natalia G
Abstract excerpt
BACKGROUND: There has been considerable interest in discovery of the genetic architecture of complex traits, particularly age-related neurodegenerative disorders. To predict disease risk and to understand its genetic basis in humans, it is necessary to study animal models. Our previous research on the accelerated-senescence OXYS strain has revealed two quantitative trait loci (QTLs) on rat chromosome 1 that are...
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