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Rat retinal transcriptome: Effects of aging and AMD-like retinopathy

1 Jun 2013

Abstract excerpt

Pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss in the elderly, remains poorly understood due to the paucity of animal models that fully replicate the human disease. Recently, we showed that senescence-accelerated OXYS rats develop a retinopathy similar to human AMD. To identify alterations in response to normal aging and progression of AMD-like retinopathy, we compared...

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PMID: 23656783
DOI: 10.4161/cc.24825

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