Article
Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci.
British journal of cancer - 14 Feb 2017
Kar Siddhartha P, Adler Emily, Tyrer Jonathan, Hazelett Dennis, Anton-Culver Hoda, Bandera Elisa V, Beckmann Matthias W, Berchuck Andrew, Bogdanova Natalia, Brinton Louise, Butzow Ralf, Campbell Ian, Carty Karen, Chang-Claude Jenny, Cook Linda S, Cramer Daniel W, Cunningham Julie M, Dansonka-Mieszkowska Agnieszka, Doherty Jennifer Anne, Dörk Thilo, Dürst Matthias, Eccles Diana, Fasching Peter A, Flanagan James, Gentry-Maharaj Aleksandra, Glasspool Rosalind, Goode Ellen L, Goodman Marc T, Gronwald Jacek, Heitz Florian, Hildebrandt Michelle A T, Høgdall Estrid, Høgdall Claus K, Huntsman David G, Jensen Allan, Karlan Beth Y, Kelemen Linda E, Kiemeney Lambertus A, Kjaer Susanne K, Kupryjanczyk Jolanta, Lambrechts Diether, Levine Douglas A, Li Qiyuan, Lissowska Jolanta, Lu Karen H, Lubiński Jan, Massuger Leon F A G, McGuire Valerie, McNeish Iain, Menon Usha, Modugno Francesmary, Monteiro Alvaro N, Moysich Kirsten B, Ness Roberta B, Nevanlinna Heli, Paul James, Pearce Celeste L, Pejovic Tanja, Permuth Jennifer B, Phelan Catherine, Pike Malcolm C, Poole Elizabeth M, Ramus Susan J, Risch Harvey A, Rossing Mary Anne, Salvesen Helga B, Schildkraut Joellen M, Sellers Thomas A, Sherman Mark, Siddiqui Nadeem, Sieh Weiva, Song Honglin, Southey Melissa, Terry Kathryn L, Tworoger Shelley S, Walsh Christine, Wentzensen Nicolas, Whittemore Alice S, Wu Anna H, Yang Hannah, Zheng Wei, Ziogas Argyrios, Freedman Matthew L, Gayther Simon A, Pharoah Paul D P, Lawrenson Kate
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have identified 18 loci associated with serous ovarian cancer (SOC) susceptibility but the biological mechanisms driving these findings remain poorly characterised. Germline cancer risk loci may be enriched for target genes of transcription factors (TFs) critical to somatic tumorigenesis. METHODS: All 615 TF-target sets from the Molecular Signatures Database were...
Read the complete abstract on PubMed